SCIENTIFIC PROGRAM RATES & INFORMATION

SCIENTIFIC PROGRAM

Wednesday, September 10^th 2008

Aula Magna

16:00 Opening Ceremony

Plenary Lectures

Chairmen: L. Frati and G. Vecchio

16:30 From experimental pathology bench to the patient’s bedside:  the contribution of experimental pathogenesis research to global health

M. E. Sobel – Executive Officer of ASIP (USA)

17:10 Nanotechnologies for the Enhancement of Human Health

J. R. Baker – University of Michigan (USA)

Thursday, September 11^th 2008

Spazio Expo 08:00 – 09:00 POSTER SESSION Abstract Session Number: A 07 HP 01,05,07,08 IN 02,04,07,09,10,16,17,18 NB 06 RR 01,03,04,06,08,12,13,15,16,17 SC 03,06,09,12 ST 19,38,59 TIM 02,05,06
Aula Magna 09:00 Innate Immunity and Inflammation I Chairs: M. Piccoli and L. Moretta “NK receptors activation and signaling” A. Santoni – University La Sapienza Roma (Italy) “Granulocyte adhesion and cell signaling transduction” G. Berton – University of Verona (Italy) 10:00 break 10:20 POSTER DISCUSSION Innate Immunity and Tumor Immunity and Microenvironment Chairs: A. Pompella and C. Caruso IN 16. Role of Chemochines/Chemochine Receptors on Leukocyte Recruitment by Lymphatic Microvessel Endothelial Cells. A. Dobrina, E. Vecile, E. Gustini, R. Cattaruzzi, A. Falcione, A. Dobrina University of Trieste, Trieste, Italy. IN 04. Polymorphisms of TLR4 and CD14 Genes and Alzheimer’s Disease Risk. C. R. Balistreri^1, M. P. Grimaldi^2, D. Lio^2, M. Chiappelli^3, F. Licastro^3, G. Colonna-Romano^2, G. Candore^2, C. Caruso^2 ^1Department of Biopathology and biomedical Methodologies, University of Palermo, Palermo, Italy. ^2University of Palermo, Palermo, Italy. ^3University of Bologna, Bologna, Italy. IN 09. Meta-Analyses of Association between Cytokine Polymorphisms and Alzheimer’s Disease S. Vasto Department of Biopathology and biomedical Methodologies, University of Palermo, Palermo, Italy IN 17. Human Airway Epithelial Cells Exhibit Contact-Mediated Cytotoxicity Upon Exposure to Multi-Walled Carbon Nanotubes: A Mechanism for Granuloma formation induced by Biopersistent Materials? B. M. Rotoli, R. Gatti, M. G. Bianchi, P. P. Zanello, E. Bergamaschi, G. C. Gazzola, O. Bussolati University of Parma, Parma, Italy. IN 18. Affinity Maturation of Antibodies in the 2-Phenyl-5-Oxazolone System. C. Scotti^1, E. Gherardi^2 ^1University of Pavia, Pavia, Italy. 2MRC-LMB, ^2Cambridge, United Kingdom (Great Britain). ST 19. Regulation of interleukin-8 Gene at a Ofstinct Site of its Promoter by C/EBP Homologous Protein in Prostaglandin E2-Treated Human T Cells. M. Cucinotta^1, M. Visalli^2, G. De Grazia^2, A. Valenti^2, S. Loddo^2, L. Altucci^3, D. Teti^2 ^1Department of Experimenthal Pathology and Microbiology, Policlinico Universitario, Messina, Italy .^2Policlinico Universitario, Messina, Italy. ^3Second University of Napoli, , Italy. ST 59. Cannabinoid Receptor Activation Commits Colon Cancer Cells to Apoptosis Via Tumor Necrosis Factor A-Induced Ceramide Synthesis L. Papucci, S. Capaccioli, F. Cianchi, N. Schiavone, M. Lulli, M. Donnini, A. Lapucci, L. Magnelli, E. Masini University of Firenze, Firenze, Italy. TIM 05. Immunogenic Cell Death Induced by Idiotype-Specific Peptides Treatment of B-Cell Llymphoma. C. Falcone^1, E. Iaccino^1, F. M. Tuccillo^2, M. Schiavone^3, S. Cariglino^4, A. De Franco^4, I. Quinto^1, C. Palmieri^1, G. Scala^1 ^1University Magna Graecia, Catanzaro, Italy.^2Fondazione G.Pascale, Napoli, Italy. ^3University of Napoli 'Federico II', Napoli, Italy.^4Biotecnology Research Center Italsistemi, Crotone, Italy. 11:20 Innate Immunity and Inflammation II Chairs: A. Mantovani and A. Santoni “Neutrophils derived cytokines in inflammatory and immune response” M. Cassatella – University of Verona (Italy) “Chemokine decoy receptors” M. Locati – University of Milano (Italy) “Receptors signaling and migration pathways of dendritic cells” S. Sozzani - University of Brescia (Italy) 12:50 lunch 14:00 Tumor Immunity and Microenvironment Chairs: A. Salerno and E. Consiglio “Inflammation and cancer” A. Mantovani – University of Milano (Italy) “Human NK cells: from the receptors to the cure of Leukemia” L. Moretta – The Giannina Gaslini Institute of Genova (Italy) “Onco-antigens as targets for preventive anti-tumor vaccination” F. Cavallo – University of Torino (Italy) “Matrix reload. The interface between tumor and cells of the immune system” M. Colombo – The National Cancer Institute of Milano (Italy) “NK cells and tumor progression” E. Carbone – University of Catanzaro (Italy) 16:30 break 16:50 ORAL COMMUNICATIONS Innate Immunity Chairs: S. Sozzani and S. Formisano IN 05. B7H Costimulation induces Caspase-1 Activation and IL-1ß Secretion in LPS-Activated Dendritic Cells and Modulates their Capacity to Drive T Cell Differentiation. A. Chiocchetti^1, S. Nicola^1, R. Mesturini^1, A. Rubartelli^2, U. Dianzani^1 ^1University of Eastern Piedmont & IRCAD, Novara, Italy. ^2Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. IN 08. Down-Regulation of the Activating Receptor NKG2D by its Ligands Expressed on T Lymphocytes: A New Mechanism to Limit Cd8+ T Cell Immune Responses. A. Zingoni, C. Cerboni, M. Ardolino, A. Santoni University la Sapienza, Roma, Italy. IN 14. Granulomatous Experimental Autoimmune Thyroiditis Induced by Immunization of CBA/J(H-2K) Mice with Hydrophobic Intermediates of the Dissociation/Unfolding of Human Thyroglobulin in Urea. D. D'Angelo^2, A. Arcaro^3, G. Cetrangolo^3, C. Luise^2, F. Febbraio^4, R. Nucci^4, F. Fulciniti^5, F. Gentile^1, S. Formisano^6 ^1Health Sciences , University of Molise, Campobasso, Italy. ^2DBPCM-University of Federico II, Napoli , Italy. ^3DiSpeS-University of Molise, Campobasso, Italy. ^4IBP-CNR, , Italy. ^5Istituto Nazionale Tumori Fondazione Pascale, , Italy. ^6University of Federico II,Napoli , Italy. IN 15. Interleukin-1 Receptor Antagonist in Ischemic Cardiomyopathy . A. Dobrina^1, E. Vecile^1, A. Falcione^1, S. Crovella^1, N. Finato^2, E. Gustini^1, S. Secchiero^1, A. Abbate^3 ^1University of Trieste, Trieste, Italy, ^2University of Udine, Udine, Italy, ^3Virginia Commonwealth University, Richmond, VA, USA.	Aula Caldora 09:00 Host Pathogens Chairs: F. Pontieri and U. Muscatello “Recent advances in the immune response of M. Tuberculosis” F. Dieli – University of Palermo (Italy) “Assessing the HIV1 – human molecular interactions in vivo” G. Scala – University of Catanzaro (Italy) “The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immune modulating agent” M. de Bernard – Venetian Institute of Molecular Medicine (Italy) 10:30 break 10:50 POSTER DISCUSSION Host Pathogens and Redox Reaction Chairs: F. Gonano and M. Sobel HP 08. The HIV-1 Matrix Protein P17 interferes with the Pi3Kinase-AKT Pathway in P17R-Expressing Cell Lines. S. Marsico^1, R. Bruno^1, S. Fiorentini^2, A. Caruso^2 ^1 University of Calabria, Arcavacata of Rende (CS), Italy. ^2 University of Brescia, Brescia, Italy. HP 07. Molecular Cloning and Characterisation of Helicobacter Pylori L-Asparaginase: A Cytotoxic Factor with Potential Biomedical Applications D. Cappelletti, M. V. Pasquetto, S. Stivala, G. Valentini, L. Chiarelli, C. Scotti University of Pavia, Pavia, Italy. RR 01. Oxidative Stress Activates a Positive Feeback Loop between the γ - and ß-Secretases Cleavages of the ß-Amyloid Precursor Protein: Role in the Pathogenesis of Alzheimer’s Disease. M. Guglielmotto^2, M. Aragno^2, R. Borghi^3, L. Giliberto^3, M. Tabaton^3, O. Danni^2, E. Tamagno^1 ^1 Department of Experimental Medicine and Oncology University of Torino, Torino, Italy. ^2 University of Torino, Torino, Italy. ^3University of Genova, Genova, Italy. ST 038. In Vitro Study of Diabetic Epithelial-Mesenchymal Transition of Renal Tubular Cells. C. Bianchi, Invernizzi, S. Bombelli, C. Chinello, P. Brambilla, V. Angeloni, B. Torsello, F. Magni, M. Galli-Kienle, R. Perego Department of Experimental Medicine- University Milano-Bicocca, Monza, Italy. RR 03. Immune Responses Triggered by Oxidative Stress in the Progression of Nonalcoholic Fatty Liver Disease. M. Vidali^2, S. Sutti^3, G. Occhino^3, C. Bozzola^3, R. Boldorini^3, E. Albano^1 ^1 Department. of Medical Sciences, University, Novara, Italy. ^2 University 'A. Avogadro' of East Piedmont, Novara, Italy. ^3 University, Novara, Italy. RR 13. Heme Oxygenase-1 Expression: Possible Therapeutic Target in Neuroblastoma Cell Lines A. Furfaro, B. Marengo, E. Balbis, J. R. Zumba Macay, C. De Ciucis, D. Cottalasso, U. Marinari, M. A. Pronzato, C. Domenicotti, N. Traverso University of Genova, Genova, Italy. RR 15. MicroRNA Expression Profiling During Human Leukemic HL-60 Cell Differentiation Induced by 4-Hydrononenal, a Product of Lipid Peroxidation. S. Pizzimenti^1, M. Ferracin^2, S. Silvia^2, C. Toaldo^1, P. Pettazzoni^1, M. U. Dianzani^1, M. Negrini^2, G. Barrera^1 ^1Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy. ^2 Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy. RR 17. Identification of 4-Hydroxynonenal-Alpha-Enolase Adducts in Hl-60 Human Leukemic Cells: Inhibition of Plasminogen Binding. F. Gentile^2, S. Pizzimenti^1, A. Alessia^2, P. Pettazzoni^1, D. D'Angelo^3, G. Mamone^4, P. Ferranti^5, C. Toaldo^1, G. P. Cetrangolo^2, S. Fomirsano^3, M. U. Dianzani^1, K. Uchida^6, G. Barrera^1 ^1Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy. ^2 Department of Science for Health, University of Molise, Campobasso, Italy. ^3 Department of Biology, Cellular and Molecular Pathology. University Federico II, , Italy. ^4 Science of Nutrition Institute, CNR, Avellino, Italy. ^5 Department of Science of Nutrition, University of Federico II, Portici , Italy. ^6 Graduate School Biagricultural Science University Nagoja, Nagoja, Japan. 11:50 ROUND TABLE A controversial issue: Infectious Disease and Atherosclerosis Chairs: A. Cassone and R. Fumarulo “Chlamydophila pneumoniae infection in cardiovascular disease” A. Cassone – Istituto Superiore di Sanità, Roma (Italy) “Chlamydia pneumoniae, Helicobacter pylori and T cells in Atherosclerosis” M. M. D’Elios – Department of Internal Medicine, Firenze (Italy) “Atherosclerosis Genetics: Diabetes gene discovery through genetic and genomic approaches” A. Attie – University of Wisconsin (USA) 12:50 lunch 14:00 ROUND TABLE Redox Reactions in Human Pathophysiology Chairs: U. Dianzani and J.Vina Introduction G. Poli – University of Torino (Italy) “Redox regulation of transcription factors: Implication in human pathophysiology” G. Mann – King’s College (UK) “Mitochondrial redox changes in male and female during ageing” J. Vina – University of Valencia (Spain) “Redox modulation of protein kinase C isoforms in cell survival or death” U. Marinari – University of Genova (Italy) “Oxidative stress. F2-Isoprostanes and liver fibrosis” M. Comporti – University of Siena (Italy) “Oxygene specie and cancer” S.A. Fuqua – University of Houston (USA) 16:30 break 16:50 ORAL COMMUNICATIONS Redox Reaction Chairs: G.Poli and G. Mann RR 05. PKC-Delta Dependent NADPH Oxidase Activation in Neuron Differentiation or Death. M. Nitti, A. L. Furfaro, C. Cevasco, N. Traverso, U. M. Marinari, M. A. Pronzato, C. Domenicotti Department of Experimental Medicine - DIMES, University of Genova, Genova, Italy. RR 11. Chemotaxis in Profibrogenic Human Hepatic Stellate Cells Requires Redox – Dependent Activation of C-Jun N-Terminal Kinase Isoforms 1 and 2 . E. Novo^2, L. Valfrè Di Bonzo^2, S. Cannito^2, D. Povero^2, C. Busletta^2, C. Bertolani^3, S. Colombatto^2, F. Marra^3, M. Pinzani^3, M. Parola^1 ^1 University of Torino, Faculty of Medicine, Torino, Italy. ^2 Department of Medicine and Experimental Oncology, Torino, Italy. ^3 Department of Internal Medicine , University of Firenze, Firenze, Italy. RR 14. 4-Hydroxynonenal (HNE), a Product of Lipid Peroxidation, Inhibits Telomerase Activity in Caco-2, a Colon Cancer Cell Line, by the inhibition of E-Box Activity of the hTERT Promoter. S. Pizzimenti^1, D. Berardi^2, C. Toaldo^3, P. Pettazzoni^3, M. U. Dianzani^3, E. Menegatti^2, G. Barrera^3 ^1Medicine and Experimental Pathology, University of Torino, Torino, Italy. ^2 Department of Medicine and Experimental Oncology, Section of Clinical Pathology, Torino, Italy. ^3 Department of Medicine and Experimental Oncology, Section of General Pathology, Torino, Italy. RR 10. Comparison of Fibroblasts from Patients Affected by Pseudoxanthoma Elasticum (Pxe) or by ß-Thalassemia with (ß-Thal-PXE+) and without PXE-Like Clinical Manifestations (ß-Thal-PXE-). F. Boraldi^2, C. Paolinelli^2, M. I. Garcia Fernandez^3, G. Annovi^2, D. Quaglino^2, R. Tiozzo^2, P. Cianciulli^4, I. Ronchetti^1 ^1Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy. ^2 University of Modena and Reggio Emilia, Modena, Italy. ^3 University of Malaga, Malaga, Spain. ^4 S.Eugenio Hospital, Roma, Italy.
Aula Magna 17:50 Plenary Lecture Chair: F. Bresciani “Spatio-temporalyl-controlled targeted somatic mutagenesis in the mouse: functional analysis of nuclear receptor signaling” D. Metzger – CNRS (Strasbourg)

End of Session Approximately at 18:35

Friday, September 12^th 2008

Spazio Expo

08:00 – 09:00 POSTER SESSION

Abstract Session Number: A 1,3,4,5,8,11 NB 1,2,3,4,5,7,8,9,11,12,13,14,16 NC 2,3,5,6,8,9,10 SC 1,2,4,10

ST 1,2,3,4,5,6,7,8,9,11,12,14,16,17,18,20,23,26,30,32,33,35,36,37,39,42,45,47,48,49,51,52,53,55,56,58,60

Aula Magna

09:00 SYMPOSIUM 1

Nutrition and Cancer

Chairs: V. Castronovo and E. Avvedimento

“Mitochondrial disease and the role of oxidative stress in cancer development and progression” V. Castronovo – University of Liege (Belgium)

“Nutrition and epigenetics – Foods that control gene expression” Z. Herceg – IARC, Lyon (France)

“Angionutrition: The role of nutrients in the control of tumor-associated angiogenesis” A. Albini –IRCCS Multimedica, Milano (Italy)

10:30 break

10:50 ROUND TABLE

Metabolic Syndrome and Cancer

Chairs: Z. Herceg and T. Pozzan

“Energy balance, adipocytokines and cancer” V. Castronovo – University of Liege (Belgium)

“Insulin resistance and prostatic cancer” M. Pollak – University of McGill (Canada)

“IGF1 and insulin receptors in cancer tissue” A. Belfiore– University of Catanzaro (Italy)

“Leptin and estrogen cross-talk in breast cancer” S. Andò– University of Calabria (Italy)

12:10 ORAL COMMUNICATIONS

Nutrition and Cancer

Chairs: A. Albini and A. Gulino

ST 27. The Role of Sgk1 in the Regulation of Sodium Absorption,Cell Proliferation, Survival and Differentiation.

N. Perrotti, R. Amato, M. Menniti, N. Perrotti - University of Catanzaro, Catanzaro, Italy.

NC 01. The Apoptotic Effects of Rosiglitazone and 9 Cis Retinoic Acid at Low Dose on Human Breast Carcinoma Cells as Markers of Benefit in Neoadjuvant Therapy of Mammary Cancer.

D. Bonofiglio¹, E. Cione¹, H. Qi¹, A. Pingitore¹, M. Perri¹, S. Catalano¹, M. Panno², G. Genchi¹, S. Andò²

¹Department of Pharmaco-Biology. ²Department of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy.

NC 07. Magnesium Deficiency Affects Mammary Epithelial Cell Proliferation: Involvement of Oxidative Stress.

V. Trapani², S. Ferrè³, J. Maier³, F. I. Wolf¹

¹General Pathology, University Cattolica del Sacro Cuore, Roma, Italy. ²University Cattolica del Sacro Cuore, Roma, Italy. ³University of Milano, Milano, Italy.

NC 13. Comparison of Colon Cancer and Breast Cancer Incidence Data from the U.S and U.K: Relationships with Folic Acid Fortification?

R. Green¹, P. Reddy², M. Hogarth², J. Miller²

¹Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA. ²University of California, Davis, Sacramento, CA, USA.

13:10 lunch

14:00 SYMPOSIUM 2

Novel Biomarkers in Oncology

Chairs: M. Lisanti and M. Sobel

Introductory remarks M. E. Sobel:– American Society for Investigative Pathology (USA)

“Epigenetic biomarkers in cancer diagnostics” W. B. Coleman – University of North Carolina at Chapel Hill (USA)

“Which way the WNT blows: stem cells in liver development and cancer” P. Monga – University of Pittsburgh (USA)

“In search of metastatic tumor cells” G. J. Tsongalis – Dartmouth Medical School (USA):

15:45 break

16:05 Awards

16:30 Plenary Lecture

Chair: S. Andò

“The potential role of micro RNA in the developing novel antitumoral pharmacological tools”

C. Croce – The Ohio State University/College of Medicine (USA)

End of Session Approximately at 17:15

Saturday, September 13^th 2008

Aula Magna 08:00 Plenary Lecture Chair: S. Ambesi “ Wnt signaling and cancer” S.A. Aaronson – Mount Sinai School of Medicine, New York (USA)
Aula Magna 08:45 ROUND TABLE Targeted therapy against human kinases: Have we made real progress in the treatment of Cancer? Chairs: A. Messina and G. Tsongalis “Suppressing EGFR tyrosine kinase activity in lung cancer: results and future perspectives” F. Ciardiello – University of Napoli 2 (Italy) “Inhibition of c-RET kinase activity for the treatment of thyroid cancer” M. Santoro – University of Napoli (Italy) “Targeting the Raf kinase in human malignancies molecular and translation issues” P. Tagliaferri – University of Catanzaro (Italy) “Inhibitors of the BCR-ABL kinase: have we cured CML?” P. Vigneri – University of Catania (Italy) 10:15 break	Aula Caldora 08:45 ORAL COMMUNICATION Host Pathogens Chairs: B. Moncharmont and N. Perrotti HP 02. HP-NAP, a Key Factor in the Helicobacter Pylori Chronic inflammation. A. Cappon, L. Cancian, G. Codolo, M. De Bernard University of Padova, Padova, Italy. HP 06. Napa of Borrelia Burgdorferi Drives Th^17 inflammation in Lyme Arthritis G. Codolo^1, A. Amedei^2, A. Polenghi3, A. C. Steere^4, C. T. Baldari^5, G. Zanotti^6, C. Montecucco^1, M. M. D'Elios^2, M. De Bernard^3 ^1 Department of Biomedical Sciences, University of Padova, Padova, Italy. ^2 Department of Internal Medicine, University of Firenze, Firenze, Italy. ^3 Venetian Institute of Molecular Medicine, Padova, Italy. ^4 Center for Immunology and Inflammatory Diseases, Division of Rheumatol, Boston, MA, USA. ^5 Department of Evolutionary Biology, University of Siena, Siena, Italy. ^6 Department of Chemistry, University of Padova, Padova, Italy. HP 10. CPS Genes of Streptococcus Pneumoniae Modulate inflammatory Response of Neutrophils P. Montemurro^1, G. Barbuti^1, M. Moschioni^2, R. Fumarulo3, P. De Rinaldis3, S. Censini^2 ^1 University of Bari, Policlinico, Italy. ^2 Novartis Vaccines, Siena, Italy.^3 University of Bari, Bari, Italy. IN 01. Do Voltage-Gated Proton Channels Play a Role in the Microbicidal Activity of Neutrophils? P. Dri, E. Decleva, F. Defendi, A. Fasolo, R. Menegazzi Department of Physiology and Pathology, University of Trieste, Trieste, Italy 09:45 POSTER DISCUSSION Signal transduction I, Stem cells Chairs: F. Gentile and and F. Curcio SC 01. Acute Myeloid Leukemia (AML) with T(^11;^19)(Q23;P^13) and Trisomy 8 shows Macrophagic Differentiation. J. F. Wang, S. Patel, M. Deleo, J. M. Valigorsky Berkshire Medical Center, Pittsfield, MA, USA. ST 48. Increased Expression of Dystroglycan Inhibits Growth and Tumorigenicity of Human Prostate Cancer Cells by Sequestering Components of the ERK-MAP Kinase Cascade. B. De Paola, M. Goracci, F. Rafanelli, A. Galiano, C. Graziani, A. Cittadini, A. Sgambato University Cattolica Sacro Cuore, Roma, Italy. SC 02. The Developing Rodent Brain: Hormonal and Environmental Influences. A. Colciago, L. Casati, P. Negri-Cesi, O. Mornati, F. Celotti Department of Endocrinology, University of Milano, Milano, Italy. ST 37. BCR-ABL Tyrosine Kinase Activity Modulates the Phosphorylation and the Localization of Interferon Regulatory Factor 5 (IRF-5) in Chronic Myeloid Leukemia Cells M. Massimino, L. Manzella, M. Fallica, M. Consoli, A. Aloisi, P. Vigneri, A. Messina Department of Biome. Sciences, Section of Gen. Pathology, University of Catania, Catania, Italy. 10:15 break
Aula Magna 10:35 Plenary Lecture Chair: S.P. Monga “Ca2 + signaling, from birth to death” T. Pozzan – University of Padova (Italy)
Aula Magna 11:20 SHORT TALKS Signal transduction I Chairs: S. Auricchio and C.Lange “Regulation of the Src/Ras/Erk pathway by steroids in breast and prostate cancers” G. Castoria University of Napoli (Italy) “Integration of MAP kinase signaling and progesterone receptor action in breast cancer models” C. Lange University of Minneapolis (USA) "Hedgehog signaling pathway and brain tumors" A. Gulino University “La Sapienza” Roma (Italy) 12:35 ORAL COMMUNICATIONS Signal transduction I Chairs: A. Attie and S.Fuqua TIM 07. Human Breast Cancer-Associated Fibroblasts Show Caveolin-1 Down-Regulation and RB Tumor Suppressor Functional inactivation. M. P.Lisanti, F. Sotgia, G. Bonuccelli, I. Mercier Cancer Biology, Kimmel Cancer Center / Thomas Jefferson University, Philadelphia, USA. ST 57. Caveolin-1 as a Target of Therapeutic Activity of Retinoid Derivatives in Osteosarcoma and Glioblastoma in Vitro. A. Gasperi-Campani^1, D. Baiocchi^1, L. Roncuzzi^2 ^1University of Bologna, Bologna, Italy.^2Istituto Ortopedico Rizzoli, Bologna, Italy. ST 41. Is GPR30 a Promiscuous Mediator of Estrogen and Antiestrogen Signals ? M. Maggiolini^1, S. Andò^2 ^1Department of Pharmaco-Biology ^2Department of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy. ST 25. Role of Differential Phosphorylation of c-Jun N-Terminal Domain in Cancer Cell Death by Genotoxic Stress. M. Vinciguerra^2, A. Madeo^1, L. Albanito^1, M. Maggiolini^1, A. M. Musti^1 ^1Department of Pharmaco-Biology, University of Calabria, Rende (CS), Italy. ^2Department of Biology and Cellular Pathology, University of Napoli, Italy. 13:35 lunch		Aula Caldora 11:20 ORAL COMMUNICATION Signal transduction II Chairs: W.Coleman and F. Stivala ST 29. EDF-1, a Novel Player in Adipogenesis. M. Leidi^2, M. Mariotti^2, J. A.M. Maier^1 ^1 Preclinical Sciences LITA Vialba, University of Milano, Milano, Italy. ^2 University of Milano, Milano, Italy. ST 43. First Evidence of Non-Genomic Estradiol induced Up-Regulation of Aromatase Enzymatic Activity in MCF-7 Breast Cancer Cells. S. Catalano^1, I. Barone^1, C. Giordano^1, P. Rizza^1, H. Qi^1, G. Gu^1, D. Bonofiglio^1, S. Andò^2 ^1Department of Pharmaco-Biology ^2Departement of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy TIM 08. The Bisphosphonate Zoledronic Acid Affects the Angiogenic Phenotype of Bone Marrow Endothelial Cells in Multiple Myeloma Patients. M. Coluccia, A. Boccarelli, R. Sasanelli, D. Giordano, P. De Rinaldis, C. Scavelli, G. Di Pietro, A. Vacca University of Bari, Bari, Italy. ST 50. Tamoxifen and Epidermal Growth Factor induce the Aggregation of MCF7 Breast Cancer Cells Up-Regulating E-Cadherin Expression. L. Mauro^1, M. Pellegrino^1, R. Lappano^2, A. Vivacqua^2, S. Andò^1, M. Maggiolini^2 ^1Department of Cell Biology, ^2Department Pharmaco-Biology, University of Calabria, Arcavacata of Rende (CS), Italy. ST 61. Bcl-2 Over-Expression in Human T-Cell Acute Lymphocytic Leukemias is Consequent to mRNA Stabilization by Increased Binding to Zeta-Crystallin, a New Bcl-2 ARE-Binding Protein. A. Lapucci^1, S. Capaccioli^1, M. Lulli^1, M. Donnini^1, N. Schiavone^1, A. Amedei^1, E. Witort^1, L. Papucci^1, S. Lazzarano^1, G. Brewer^2, D. Morello^3 ^1University of Firenze, Firenze, Italy. ^2Robert Wood Johnson Med Sch, Univ of Medicine and Dentistry of NJ, Piscataway, NJ, United States Minor Outlying Islands. ^3Centre de Biologie du Développement, Toulouse, France. ST 44. Androgen Receptor (AR) Inhibits Cyclin D1 Promoter Activity. May AR be considered as an Oncosuppressor in Breast Cancer? M. Lanzino^1, D. Sisci^1, C. Garofalo^1, C. Morelli^1, S. Catalano^1, I. Casaburi^1, S. Andò^2 ^1Department of Pharmaco-Biology ^2Department of Cell Biology, University of Calabria, Arcavacata of Rende (CS), Italy. TIM 04. Immunopathological Alterations of the Prostate-Associated Lymphoid Tissue (PALT) by Androgen Ablation in Patients with Prostate Cancer. C. Sorrentino, T. D'Antuono, S. Rosini, P. Musiani, E. Di Carlo Department of Oncology and Neurosciences, ‘G. d'Annunzio’ University, Chieti, Italy. ST 46. Insulin Receptor Substrate 1 Modulates the Transcriptional Activity and the Stability of Androgen Receptor in Breast Cancer Cells. D. Sisci^1, M. Lanzino^1, C. Garofalo^1, C. Morelli^1, I. Casaburi^1, S. Andò^2 ^1Department of Pharmaco-Biology, ^2Department of Cell Biology , University of Calabria, Arcavacata of Rende (CS), Italy ST 31. Myostatin Blockade by Deacetylase Inhibitors Fails to Counteract Muscle Wasting in Tumor-Bearing Mice F. Penna, A. Bonetto, P. Reffo, V. G. Minero, G. Bonelli, F. M. Baccino, P. Costelli Department. of Experimental Medicine and Oncology, Torino, Italy. 13:35 lunch
14:30 POSTER DISCUSSION Signal transduction II, novel biomarkers in oncology Chairs: A. Gaspari Campani and E.Jirillo ST 01. Cyclooxygenase-2 (Cox-2) Regulating Transcriptional and Post-Transcriptional Activation of Aromatase is involved in Leydig Cell Tumor Proliferation. A. Chimento^1, R. Sirianni^1, A. De Luca^1 , A. Carpino^2, V. Rago^2, M. Maggiolini^1, S. Andò^2, V. Pezzi^1 ^1Department of Pharmaco-Biology ^2Department of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy. ST 07. Genome-Wide Mapping of Estrogen Receptor Alpha Binding to Chromatin in Breast Cancer Cells by Massively Parallel Sequencing (ChIP-Seq) O. Paris, L. Cicatiello, L. Ferraro, O. M.V. Grober, M. Mutarelli, R. Tarallo, A. Weisz Department of General Pathology, SUN, Napoli, Italy. ST 49. Breast Cancer Cells Expressing the K303R ERα Mutant are Resistant to an Aromatase Inhibitor. I. Barone^1, Y. Cui^1, S. Andò^2, S. A.W. Fuqua^1 1Breast Center, Baylor College of Medicine, Houston, TX, USA.^2Department of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy NB 16. Idiotype-Specific Peptides as Tools for the Specific Delivery of Therapeutic Compounds into Tumors. E. Iaccino^1, C. Falcone^2, F. Tuccillo^3, M. Schiavone^4, S. Cariglino^5, A. De Franco^6, I. Quinto^1, C. Palmieri^1, G. Scala^1 ^1Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro, Italy. ^2University of Catanzaro, Catanzaro, Italy. ^3Department of Experimental Oncology, National Cancer Institute -INT “,Neaples,Italy. ^4Department of Biochemistry and Medical Biotechnology, University of Napoli, Italy. ^5Biothecnology Research Center Italsistemi, Crotone, Crotone, Italy. ^6Biothecnology Research Center Italsistemi, Crotone, Crotone, Italy. NC 03. CLA Response of Human Breast Cancer Cells: Mechanisms Involved C. Bocca, F. Bozzo, S. Cannito, S. Colombatto, A. Miglietta Experimental Medicine and Oncology, University of Torino, Torino, Italy. NB 14. Exploring Mutant P53 Gain of Functions in Vivo Through Conditional RNA interference. G. Bossi^1, F. Marampon^2, B. Zani^2, G. Blandino^3, A. Sacchi^4 ^1Experimental Oncology, Regina Elena Cancer Institute, Roma, Italy. ^2University of L'Aquila, L’Aquila, Italy. ^3Roma Oncogenomic Center, Regina Elena Cancer Institute, Roma, Italy. ^4Regina Elena Cancer Institute, Roma, Italy. 15.15 ROUND TABLE Ageing: Systems Biology and Longevity Chairs: E. Ronchetti and L. Mc Manus “The proteomic approach to the ageing:The human fibroblast model” D. Quaglino – University of Modena and Reggio Emilia (Italy) “Inflammatory mediators: a pharmacogenomic approach in Alzheimer’s disease” C. Caruso – University of Palermo (Italy) “A powerful approach to identify innovative anti-ageing targets and strategies” C. Franceschi – University of Bologna (Italy) and G. De Benedictis – University of Calabria (Italy) 16.45 ORAL COMMUNICATIONS Ageing Chairs: C. Franceschi and G. De Benedictis A 10. Cxcr3 Chemokine Receptor Facilitates Dermal and Epidermal Maturation in Aged Associated Wounds. C. C. Yates, D. Whaley, A. Wells University of Pittsburgh, Pittsburgh, PA, USA. A 09. A Clinical, Pathological and Molecular Study of A Frontotemporal Dementia Sporadic Case. M. A. Losso^1, R. Vuono^1, M. Anfossi^2, L. Bernardi^2, R. Colao^2, C. Duyckaerts^5, J.F. Foncin^6, F. Frangipane^2, M. Gallo^2, S. Geracitano^2, F. Lamenza^3, R. Maletta^2, M. L. Panno^1, G. Puccio^2, M. G. Spillantini^4, C. Tomaino^2, A. C. Bruni^2 ^1Department of Cell Biology, University of Calabria, Arcavacata of Rende (CS), Italy. ^2Regional Neurogenetic Centre, AS 6, Lamezia Terme, Italy. ^3Geriatric Unit, AS3, Rossano, Italy. ^4Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Great Britain). ^5Laboratoire de Neuropathologie R. Escourolle, Hôpital de La Salpêtriè, Paris, France.^6Laboratoire de Neurohistologie, Ecole Pratique des Hautes Etudes, Brie Comte Robert, France A 06. Involvement of Myosin II-B and Protein Kinase C in the Processing of the Alzheimer Amyloid Precursor Protein F. Argellati^2, S. Massone^2, C. Domenicotti^2, B. Marengo^3, U. M. Marinari^2, M. A. Pronzato^2, R. Ricciarelli^1 1Department of Experimental Medicine, University of Genova, Genova, Italy. ^2University of Genova, Genova, Italy. ^3University of Genova and G. Gaslini Institute, Genova, Italy.		14:30 ORAL COMMUNICATION Signal transduction III, Stem Cells, Novel biomarkers in Oncology Chairs: M. Maggiolini and A. Weisz ST 15. Evidences that Bergapten is an Antitumoral Agent that Enhances P53 Gene Expression Independently of its Photoactivation. M. L. Panno^1, F. Giordano^1, V. Rago^1, V. Bartella^2, M. G. Palma^1, D. Bonofiglio^2, F. De Amicis^2, E. Cione^2, S. Andò^1 ^1Department. of Cell Biology, ^2Department of Pharmaco-Biology, University of Calabria, Arcavacata of Rende (CS), Italy ST 21. Enhanced Anti-Tumor Therapy by Inhibition of p^21waf1 in Human Malignant Mesothelioma. R. Lazzarini, S. Moretti, S. Di Nuzzo, S. Orciari, M. Russo, A. Procopio, A. Catalano Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy. ST 34. Sgk1 Promotes Cell Proliferation, Survival and Epithelial De-Differentiation by Activating HDM2-Dependent P53 Degradation. R. Amato, L. D’Antona, G. Porciatti, M. Menniti, N. Costa, N. Perrotti Experimental and Clinical Medicine, Department of Experimental and Clinical Medicine, UMG University, Catanzaro, Italy. ST 40. Induction of ErbB-^3 Expression by Alpha6Beta4 Integrin Contributes to Tamoxifen Resistance in ERbeta1-Negative Breast Carcinomas R. Falcioni^1, V. Folgiero^1, G. Bon^1, S. Di Carlo^1, S. Andò^2, A. Sacchi^1 ^1Regina Elena Cancer Institute, Roma, Italy. ^2Department of Cell Biology University of Calabria, Arcavacata of Rende (CS), Italy SC 05. Bone Marrow – Derived Mesenchymal Stem Cells Engraft Chronically Injured Liver and Differentiate into Pro-Fibrogenic Myofibroblast-Like Cells: The Role of PDGF-BB. L. Valfrè Di Bonzo^2, E. Novo^2, S. Cannito^2, C. Busletta^2, K. Mareschi^3, D. Rustichelli^3, M. Gunetti^3, S. Colombatto^2, F. Fagioli^3, M. Parola^1 ^1University of Torino, Faculty of Medicine, Torino, Italy. ^2Dipartment of Medicine and Experimental Oncology, Torino, Italy. ^3Dipartment of Pediatric Sciences, Torino, Italy. SC 07. Dental Pulp Marrow Similar Cells (D.P.M.S.C.): A New Source of Stem Cells for Clinical Applications. F. Ferro^1, R. Spelat^1, F. D'Aurizio^1, E. Puppato^1, M. Pandolfi^1, A. P. Beltrami^1, D. Cesselli^1, C. A. Beltrami^1, F. Curcio^1 ^1DPMSC - CIME, University' of Udine, Udine, Italy. SC 08. Subpopulations of Stem Cells Exist in Bone Marrow Which Show Specific Homing Abilities in Uninjured Hosts. M. Moretti, M. Bottecchia, M. Toller, N. Bergamin, R. Spelat, A. P. Beltrami, D. Cesselli, C. A. Beltrami, F. S. Ambesi Impiombato, F. Curcio, F. Ferro DPMSC - CIME, University of Udine, Udine, Italy. SC 11. Plasticity of Third Trimester Placental Stem Cells. R. Sala, A. Bianchera, L. Reia, G. Gazzola University of Parma, Parma, Italy. NB 10. Protein Clusters Predictive of Therapeutic Response in Breast Cancer Patients. A. Barchetti^1, L. Cortesi^2, L. Della Casa^1, E. Rossi^1, M. Federico^1, A. Iannone^1 ^1University of Modena and Reggio Emilia, Modena, Italy. ^2Azienda Ospedaliera of Modena, Modena, Italy. NB 15. Imatinib Mesylate Resistance by T315I Mutation and its Prevalence in Indian Chronic Myeloid Leukemia Patients (First Study from India). A.B. R. Mir, Department of Hematology, All India Institute of Medical Sciences, NEW DELHI, India.
17:30 POSTER DISCUSSION Ageing Chairs: L. Mc Manus and M. Sobel A 01. Familial Late Onset Dementia: From Complex to Monogenic Model R. Maletta^1, M. Anfossi^2, L. Bernardi^2, R. Colao^2, F. Frangipane^2, M. Gallo^2, S. Geracitano^2, G. Puccio^2, C. Tomaino^2, A. C. Bruni^2 ^1Centro Regionale di Neurogenetica. ^2ASP Catanzaro Ospedale Lamezia Terme, Lamezia Terme, Italy. A 11. Loss of Cxc Chemokine Receptor 3 Signaling Causes a Delay in Epidermal and Dermal Maturation and Leads to Hypertrophic Scarring. C. Yates, D. Whaley, R. Bodnar, A. Wells University of Pittsburgh, Pittsburgh, PA, USA. A 03. Molecular Characterization of Thirty-Five Italian Patients with Niemann-Pick C: Identification of 21 Npc1 and 1 Npc2 Novel Alleles. P. Tarugi^1, E. Pinotti^1, T. Fancello^1, C. Romano^3, M. Filocamo^2 ^1Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy. ^2IRCCS G. Gaslini, Genova, Italy. ^3Bioinformatica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. A 04. Oxidative Stress and UV Radiation-induced Effects on Human Primary Thyroid Cell Proliferation. I. Kostic^1, B. Toffoletto^2, M. Toller^3, M. Moretti^3, C. A. Beltrami^2, F. S. Ambesi Impiombato^3, F. Curcio^3 ^1Institute of Pathophysiology, School of Medicine, Kragujevac, Serbia. ^2Department of Morphological sciences, sez. of Anatomy Pathology, University of Udine, Italy.^3Department of Pathology and Experimental and Clinical Medicine, University of Udine, Italy. A 05. Polymorphisms of the Eicosanoid Enzymes in Myocardial infarction and Longevity: Implications for Pharmacogenomics. F. Listì, C. Caruso, M. Caruso, E. Incalcaterra, E. Hoffmann, G. Caimi, D. Di Carlo, S. Vasto, D. Lio, G. Candore University of Palermo, Palermo, Italy. A 08. Cystatin-C, Apo-E Polymorphisms and Alzheimer'S Disease: An Association Study in Southern Italy. V. Andreoli, F. Trecroci, A. La Russa, N. Romao, G. Di Palma, G. Nicoletti, R. Cittadella ISN-CNR, Mangone, Italy.		17:00 POSTER DISCUSSION Signal transduction III, Stem Cells,Novel biomarkers in Oncology Chairs: A. Sacchi and M.. Bifulco ST 02. Silencing of Survivin induced by a BCR-ABL/JAK2/STAT3 Pathway Kills CML Cells and Sensitites IM-Resistant Clones To Hu. S. Stella^1, E. Tirrò^1, E. Conte^1, E. Palio^1, L. Manzella^1, D. Altieri^2, A. Messina^1, P. Vigneri^1 ^1University of Catania, Department of Science Biomedical,Section of General Pathology, Catania, Italy. ^2University of Massachusetts Medical School, Department of Cancer Biology, Worchester, MA, USA. ST 51. Identification and Analysis of Mouse DAG-1 Gene-Promoter and Evaluation of its Activity During Muscle Differentiation. A. Rettino, F. Rafanelli, M. Goracci, B. De Paola, C. Graziani, A. Cittadini, A. Sgambato University Cattolica del Sacro Cuore, Roma, Italy. SC 04. Identification and Characterization of Cells with Stem/Progenitor Properties in Normal Kidney and in Renal Cell Carcinoma. C. Bianchi^1, S. Bombelli^1, M. Casu^2, G. Bovo^3, L. Invernizzi^1, P. Brambilla^1, G. Cattoretti^4, G. Strada^2, R. Perego^1 ^1Department of Experimental Medicine, Milano-Bicocca University, Monza, Italy. ^2Urology Unit, S. Gerardo Hospital, Monza, Italy. ^3Pathology Unit, S. Gerardo Hospital, Monza, Italy. ^4Department of Surgical Science, Milano-Bicocca University, Monza, Italy. SC 10. Energetic Metabolism and CFTR Expression and Function in Murine Hematopoietic Stem Cells. D. Piro^1, C. Piccoli^1, L. Guerra^2, A. D'Aprile^1, M. Favia^2, R. Fumarulo^2, A. B. Maffione^1, N. Capitanio^1, V. Casavola^2, M. Conese^1 ^1University of Foggia, Foggia, Italy. ^2University of Bari, Bari, Italy. ST 30. HD-PTP is a Negative Regulator of the Migration of T24 Human Bladder Carcinoma Cells. S. Castiglioni, E. Baldoli, J. A.M. Maier, M. Mariotti University of Milano, Milano, Italy. ST 35. Multiple Molecular Mechanisms Sustain Hypoxia - Dependent Epithelial - Mesenchymal Transition and Increased Invasiveness in Human Cancer Cells. S. Cannito^2, E. Novo^2, A. Compagnone^2, L. Valfrè Di Bonzo^2, C. Busletta^2, A. Bandino^2, F. Bozzo, S. Colombatto^2, M. Parola^1 ^1University of Torino, Faculty of Medicine, Torino, Italy. ^2Dipartment of Medicine and Experimental Oncology, Torino, Italy. NB 03. Modification of a Specific Protein Pattern as Potential Indicator of Ovarian Cancer Progression. E. Rossi, A. Barchetti, L. Cortesi, M. Federico, A. Iannone University of Modena and Reggio Emilia, Modena, Italy. NB 04. Concentration of Plasma DNA for Monitoring Patients with Renal Carcinoma. P. Brambilla^1, C. Bianchi^1, E. Fasoli^2, S. Bombelli^1, L. Invernizzi^1, B. Torsello^1, V. Angeloni^1, C. Battaglia^3, F. Magni^1, G. Galasso^4, R. Perego^1 ^1Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy. ^2Department of Medicine, Surgery & Dent, S. Paolo Hospital, University of Milano, Milano, Italy. ^3Department of Biomedical Sciences & Technologies & CISI, University of Milano, Milano, Italy. ^4Institute of Urology, IRCCS Policlinico, University of Milano, Milano, Italy. NB 01. Control of Tumor Growth by the Endogenous Cannabinoid System in Colon Cell Lines M. G. Caruso Nutritional Biochemistry, National Institute for Digestive Diseases, Castellana Grotte (BA), Italy. NB 11. Molecular and Proteomic Characterization of Primary Cell Cultures from Normal Kidney and Renal Cell Carcinoma. C. Bianchi^1, S. Bombelli^1, L. Invernizzi^1, C. Chinello^1, B. Torsello^1, V. Angeloni^1, P. Brambilla^1, F. Raimondo^1, V. Proserpio^2, S. Casellato^3, S. Ferrero^4, F. Magni^1, R. Perego^1 ^1Department of Experimental Medicine, Milano-Bicocca University, Monza, Italy. ^2Department of Laboratory Medicine, Desio Hospital, Desio, Italy. ^3Institute of Urology, IRCCS Policlinico, University of Milano, Milano, Milano, Italy. ^4Department of Medicine, Surgery and Dentistry, University of Milano, Milano, Italy.

18:15 End of meeting